The Hardy-Weinberg Principle
General Biology Independent Laboratory Experiences for the College Science Major
Second Semester
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The Hardy-Weinberg Principle
Version 09-1.01
Exercise 1: The Hardy-Weinberg Equilibrium Model
Hitchhiker’s
Thumb
Thumbs with end joints that can be bent back at 45ď‚° are 100% recessive (ss).
Thumbs that cannot bend back significantly are dominant (either SS or Ss).
SS, Ss
Students’ Results:
Results:
Use Example 1 as a guide and the students’ data above to determine the allelic frequencies for the gene using the equations proposed by Hardy-Weinberg to support the equilibrium theorem.

Show that the allelic frequencies will not change over time.
Suggest conditions that could change these frequencies. What would the effects of the conditions be?
Exercise 2: Evolution and Genetic Drift
Results:
Table 1: Student’s Results for an Ecological Study to Determine Genetic Drift
Due to Selective Foraging Pressure by a Kestrel
generation
# of brown
grasshoppers
# of green
grasshoppers
For purposes of calculation: Let p = the frequency of the dominant allele, B.
Let q = the frequency of the recessive allele, b.
? can denote either B or b. Why?

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