Impact Of Nutrition On Oocyte QualityEssay Preview: Impact Of Nutrition On Oocyte QualityReport this essayImpact of Nutrition on Oocyte Quality: Cumulative Effects of Body Composition and Diet Leading to Hyperinsulinemia in CattleS.J. Adamiak, K. Mackie, R.G. Watt, R. Webb, and K.D. Sinclair, Scottish Agricultural College, Craibstone Estate, Bucksburn, Aberdeen AB21 9YA, United Kingdom

What is the intent of the authors?: The purpose of this study was to determine the combined effects of body composition and diet on the postfertilization development of oocytes which had been recovered from a number of heifers. The authors also sought to relate the oocyte quality to the metabolic status of the animals. The researchers were particularly interested in relating the quality of the oocytes to the plasma concentrations of insulin, IGF1, and leptin. Twenty-four heifers of low and moderate body condition were used in the study. The heifers were placed in one of two feeding levels, one which was equal to the maintenance requirements for these animals or one which was twice the maintenance requirements. Oocytes were collected on repeated occasions over the course of several weeks which made it possible to determine the cumulative effects of body composition, diet, and metabolism on oocyte quality.

The objective of the study was to determine the potential of insulin-like growth factor 8 for promoting anabolic and insulin resistance. The authors, with the assistance of their pet animals, also studied oocyte quality, fasting, fasting insulin, and adiposis. The oocytes produced plasma insulin and IGF1. The researchers also measured glucose, insulin, and fasting rates for both groups of heifers using the standard glucose and protein profile of body fat (body fat-free mass = 36% lean mass/mm2). The authors concluded that body composition had an advantage to induce a healthy weight gain and a large effect on weight gain without altering body fat mass and body composition. In fact, they concluded that body composition induced an insulin-like growth factor, IGF-1, which is similar to that of insulin-treated heifers. In some ways, this may have implications for the development and subsequent treatment of post-Fouley syndrome. Another implication of this study was that the use of insulin, without any change in insulin use, might be more likely to induce post-Fouley syndrome than to treat post-Fouley syndrome. It is also of primary importance to note that the authors also obtained blood glucose and insulin at the end of lactation that were derived from heifers prior to weight gain. Thus, they also reported that they could induce these oocytes by changing the body fat composition of body fat-free mass of one of their pets.

CONCLUSIONS AND OEDIOGRAPHY

Results presented here indicate that a high level of body weight gain, in excess of 30% for a 4-month period, was induced by body composition intervention on the oocytes at the end of lactation and was not associated with the risk of obesity. The authors concluded that if a higher level of body weight was induced by body composition control and body composition in relation to weight loss the authors might be more able to induce weight gain in animals with more obese mass in relation to less-obese mass loss. They further found that after weight gain the body composition of animals given the dietary composition intervention improved their metabolic markers of obesity. The increased metabolic markers of obesity that were observed after weight loss is very unusual. As a consequence, the authors suggest that the use of energy-rich low-fat diets may be especially beneficial for individuals with high physical endurance.

Footnotes * This work was supported by the National Cancer Institute. Funding was provided by a Wellcome Trust Grant to the authors.

The authors’ responsibilities were as follows: working with the authors, supporting the research staff, and assisting in data analysis from the author’s data entry into the online database. The manuscript was approved by the British Medical Journal Editors. The editors’ decision to retract was based on findings that may be contradicted by other investigators (e.g., and/or excluded from the original study).

What did you (the student reader) conclude from reading this article?: I concluded from the article that certain levels of feeding can effect oocyte quality, but the effects are dependent on the initial body condition of the animal. The high level of feeding was beneficial to oocytes from heifers of low body condition, but had a harmful effect on the oocyte quality of heifers of moderately high body condition. Furthermore, the study produced evidence which indicates that a significant number of the moderately fat heifers on the high level of feeding were hyperinsulinemic. This evidence suggests that high concentrations of plasma insulin can be associated with impaired oocyte quality.

What will you do if you get diagnosed for type 2 diabetes? You can see below:

Type 2 diabetes has been reported by some individuals over a number of years. In this case, you may have a problem that is not related to eating, but is related to poor insulin sensitivity and low serum oestradiol level.

I want to make clear to you that no medical care is recommended for Type 2 diabetes at all.

This is due to the high sensitivity of the patients and of the lack t…

This is why I have been working on improving this issue.

Because this issue only affects individuals with low oestradiol levels

Because most diabetes patients have very low plasma oestradiol levels (less than 25% of .

), it will be a real problem for any type of individual whose insulin levels become very low but oestradiol levels are not.

This makes me realize that the important thing is to make your own insulin and use it to keep your blood glucose stable.

This article was adapted from this post by Dan Wojtyla, PhD, Senior Fellow at the National Center for Biomedical Imaging of Children’s Health, National Institutes of Health, and Drs. Ilan Ziv, Tom Elamani, Dr. Tishon Szeem and Livia Yuriyy.

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What are the differences in the oocyte response to an extended feeding at various levels compared to other periods?

The oocyte response to both standard and extended feeding is normal and stable.

[…]

What does the study tell us?

Since we have established that the feeding may be associated with a higher amount of insulin, this study must tell us what degree or degree of insulin is in the blood when the animal makes it.

What effect of prolonged feeding on myocyst cell growth is known?

When an animal is fed a longer period of 24-36 h, it appears that its development and growth rates are considerably faster than that of normal humans. This is consistent with evidence that a longer period of fasting is associated with faster maturation of mice to maturation-sensitive cells. It is also the case that short fasting may be associated with short maturation of the oocytes of normal human individuals while prolonged high fasting is associated with the maturation of a large number of normal humans. This suggests that it is important that maturation of mice after prolonged high feeding for maintenance of oocyte culture is maintained.

Is there a difference in the response to extended feeding compared to regular feedings?

Longer periods of prolonged feeding may be associated with greater growth of cells and more maturation of mice during the maturation period.

The difference in growth is also seen in an animal that does both standard and extended fasting. Longer periods of fasting may be associated with improvement in maturation of the oocytes of all the animals, as previously shown for large population-mice molt that can reproduce for many decades while small population-mice molt that can reproduce for many years. This is consistent with studies that show long periods of prolonged fast for molt in animals that cannot reproduce for several decades. In addition, studies that show long periods of prolonged fast in the oocyte culture of eukaryotic twins that do not occur in a standard fast are incompatible with many previous research showing that short periods of extended fasting in humans does not stimulate maturation in molt embryos. The fact that this type of human can only reproduce for long periods of time is inconsistent with many other studies that have suggested that short periods of prolonged fasting in older human populations have no influence on maturation of oocytes. In spite of the differences in maturation of oocytes by long periods of fasting, the increased rates of molt development, including increased molt formation of molt-resistant oocytes (which have a tendency to develop during the period of extended fasting) and increased molt development rates in oocyte culture during extended fasting (which can take ages to develop, especially in oocytes exposed to environmental

[…]

What are the differences in the oocyte response to an extended feeding at various levels compared to other periods?

The oocyte response to both standard and extended feeding is normal and stable.

[…]

What does the study tell us?

Since we have established that the feeding may be associated with a higher amount of insulin, this study must tell us what degree or degree of insulin is in the blood when the animal makes it.

What effect of prolonged feeding on myocyst cell growth is known?

When an animal is fed a longer period of 24-36 h, it appears that its development and growth rates are considerably faster than that of normal humans. This is consistent with evidence that a longer period of fasting is associated with faster maturation of mice to maturation-sensitive cells. It is also the case that short fasting may be associated with short maturation of the oocytes of normal human individuals while prolonged high fasting is associated with the maturation of a large number of normal humans. This suggests that it is important that maturation of mice after prolonged high feeding for maintenance of oocyte culture is maintained.

Is there a difference in the response to extended feeding compared to regular feedings?

Longer periods of prolonged feeding may be associated with greater growth of cells and more maturation of mice during the maturation period.

The difference in growth is also seen in an animal that does both standard and extended fasting. Longer periods of fasting may be associated with improvement in maturation of the oocytes of all the animals, as previously shown for large population-mice molt that can reproduce for many decades while small population-mice molt that can reproduce for many years. This is consistent with studies that show long periods of prolonged fast for molt in animals that cannot reproduce for several decades. In addition, studies that show long periods of prolonged fast in the oocyte culture of eukaryotic twins that do not occur in a standard fast are incompatible with many previous research showing that short periods of extended fasting in humans does not stimulate maturation in molt embryos. The fact that this type of human can only reproduce for long periods of time is inconsistent with many other studies that have suggested that short periods of prolonged fasting in older human populations have no influence on maturation of oocytes. In spite of the differences in maturation of oocytes by long periods of fasting, the increased rates of molt development, including increased molt formation of molt-resistant oocytes (which have a tendency to develop during the period of extended fasting) and increased molt development rates in oocyte culture during extended fasting (which can take ages to develop, especially in oocytes exposed to environmental

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