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Chemtract Essay Preview: Chemtract Report this essay The tethered agonist approach to mapping ion channel proteins – toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor. Research by Lintong Li, Wenge Zhong, Niki Zacharias, Caroline Gibbs, Henry A Lester, Dennis A. Dougherty. Condensation of the Research Purpose of the Study:.