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Neurochemistry Of Epilepsy Essay Preview: Neurochemistry Of Epilepsy Report this essay Neurochemistry of Epilepsy Epileptic seizures have been described and recognized for millennia. One of the earliest descriptions of a secondarily generalized tonic-clonic seizure was recorded over 3000 years ago in Mesopotamia. The first book about epilepsy was written by Hippocrates about 2500 years ago..