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Endocannabinoids Case Essay Preview: Endocannabinoids Case Report this essay Endocannabinoids are a group of lipid messengers that act on specific cell surface receptors. The endocannabinoid system consists of two cannabinoid (CB) receptors, seven ligands, and ligand-catabolizing enzymes such as fatty acid amid hydrolase (FAAH) and monoglyceride lipase (MGL). It is phylogenetically ancient, occurring in vertebrates.