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Systemic Lupus ErythematosusEssay Preview: Systemic Lupus ErythematosusReport this essay1) Systemic lupus erythematosus (“SLE”) is a very serious, usually incurable and often fatal disease resulting (at least in large part) from production of a whole series of different anti-self antibodies, including antibodies against DNA (both double stranded and single stranded), phospholipids, collagen, histones and RNA. Note.