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Mrs Samsa Vs. Lady Macbeth Even though both Lady Macbeth and Mrs. Samsa react negatively to Macbeth and Gregor’s transformations, their reaction’s impact on Macbeth and Gregor differ. Lady Macbeth does not attempt to change Macbeth back into a loving husband. Her initial reaction of disappointment and anger after Macbeth kills Duncan soon flips upside.